Canting Keel Omega-3 Platinum

 97,00

  • 100 Softgels
  • 1000mg EPA & 500mg DHA per Serving
  • Powerful Anti-inflammatory
  • Enhance & Improve Bone & Joint Health
  • Premium Quality for Superior Absorption

Omega 3 fatty acids are some of the most important nutrients you can put in your body.

Not only are they extremely anti-inflammatory, but they actually make up some of the most important structures of your body like your brain & nervous system.

Not getting enough Omega 3 fats in your diet increases your risk of many chronic illnesses.

Omega-3 fatty acids are incorporated into cell membranes, and play a role in anti-inflammatory processes and cell membrane viscosity.
EPA and DHA are essential for proper brain development and function. It is well-known that omega-3 fatty acids are able to mitigate inflammation.
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Omega 3 Platinum is a type of essential fatty acid that powers your brain, heart, and joints.

Your body can’t produce these fats on its own — you have to get them from a supplement or from food.

There are different kinds of omega-3s: EPA and DHA. Most fish oil supplements contain a combination of EPA and DHA, since they each carry benefits and complement each other.

You also want to make sure you have the right ratio of omega-3s and omega-6s (another type of essential fatty acid). For most people, the ideal ratio is 1:1.

Since it’s not easy knowing whether you’ve got the balance right, taking an omega-3 supplement gives you peace of mind that you’ve covered your bases. Fish and krill oil supplements both contain EPA and DHA, but they each carry different benefits.

By now you probably know that omega-3s are a really good thing — they’re vital to keeping your mind and your body in working order. Fatty fish or a high-quality omega-3 supplement power your brain, protect your heart, and oil your joints.

Omega-3s are a type of essential fatty acid that are vital to fueling your brain, keeping you full, and more. Your body can’t produce these fats on its own — you have to get them from a supplement or from food. The best food sources are fatty fish, grass-fed beef, pastured egg yolks, and leafy greens.

There are different kinds of omega-3s:

  • EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid): Both come from animal sources. Most fish oil supplements contain a combination of EPA and DHA, since they each carry benefits and complement each other.
  • ALA (alpha-linolenic acid): ALA comes mostly from plant sources. Humans can only convert up to 9% of ALA to DHA.

Since it’s not easy knowing whether you’ve got the balance right, taking an omega-3 supplement gives you peace of mind that you’ve covered your bases.

Canting Keel Omega-3 Platinum Key Benefits

  • Supports brain health
  • Supports heart health
  • Strengthens your brain
  • Keeps skin supple and smooth
  • Fights free radicals

Suggested Use

Take one (1) soft gel capsule daily, preferably with a meal or as directed by a healthcare practitioner.

Ingredients

Fishoil 50/25, Gelatine, Glyerin, Purified water

Additional product information

If you are pregnant, nursing, taking any medications, have any medical condition, or are planning to undergo any clinical lab testing, please consult your healthcare practitioner before taking any dietary supplement.
Discontinue use and consult your healthcare practitioner if any adverse reactions occur. Not intended for use by persons under the age of 18. Keep out of reach of children. Store at room temperature. Do not use if the outer bottle seal is missing or damaged.

Research Studies

The Role of Physical Exercise and Omega-3 Fatty Acids in Depressive Illness in the Elderly

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843982/

Dietary sources of the longer omega-3 fatty acids, as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), include marine algae, animals, and phytoplankton. Fish, squid, and krill oils are rich in EPA and DHA.

Omega-3 fatty acids are incorporated into cell membranes, and play a role in anti-inflammatory processes and cell membrane viscosity. EPA and DHA are essential for proper brain development and function from childhood to old age. DHA is a key component of neuronal membranes and contributes to synaptic membrane fluidity and regulation of cell signaling. EPA and DHA are also the precursors of anti-inflammatory and pro-resolving lipid mediators, such as resolvins and protectins, considered to be beneficial in the treatment and prevention of numerous diseases.

The increased prevalence of depressed mood and anxiety over the last decades has been associated with an excessive consume of saturated fats and refined sugar, as well as with a raise in the ratio of omega-6 to omega-3 fatty acids. In particular, nutritional research indicates that the “Western diet” does not provide the aged brain with an optimal supply of omega-3 fatty acids.

It is well-known that omega-3 fatty acids are able to mitigate inflammation. For example, rats that consumed omega-3 fatty acid-deficient diets from birth showed higher plasma levels of IL-6, C-reactive protein, and TNFα, which were reversed by subsequently feeding them with an ALA-containing diet. In addition, EPA modulates the immune function by reducing membrane arachidonic acid and prostaglandin E2 synthesis. Thus, another potential mechanism for the antidepressant action of omega-3 fatty acids is via regulation of neuroinflammation and oxidative stress. In fact, omega-3 fatty acids show inverse associations with depressive symptoms among individuals with higher oxidative stress levels. Furthermore, several types of research indicate that omega-3 fatty acids may exert antidepressant effects when depression is associated with inflammation. As for human studies, a randomized controlled trial found that EPA is able to prevent depression in hepatitis C virus patients which received interferon-α therapy. Omega-3 fatty acids have been reported to attenuate both endotoxin-induced inflammation and sickness behavior in rodents and humans. In rats, omega-3 fatty acid administration alleviated the behavioral, inflammatory, and oxidative stress consequences of the treatment with doxorubicin, a chemotherapeutic agent widely used in human malignancies whose long-term use may provoke depression. Anti-inflammatory properties of omega-3 fatty acids were reported even at an old age.

The Influence of Omega-3 Fatty Acids on Skeletal Muscle Protein Turnover in Health, Disuse, and Disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742725/

Ingestion of omega-3 fatty acids is known to exert favorable health effects on a number of biological processes such as improved immune profile, enhanced cognition, and optimized neuromuscular function. Recently, data have emerged demonstrating a positive influence of omega-3 fatty acid intake on skeletal muscle. For instance, there are reports of clinically-relevant gains in muscle size and strength in healthy older persons with omega-3 fatty acid intake as well as evidence that omega-3 fatty acid ingestion alleviates the loss of muscle mass and prevents decrements in mitochondrial respiration during periods of muscle disuse.

In summary, the available evidence would suggest that omega-3 fatty acid intake has the potential to enhance skeletal muscle anabolism, but the magnitude of the effect may be dependent upon a number of factors.

Omega-3 Fatty Acids as a Treatment for Pediatric Depression.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892434/

Depressive disorders in childhood and adolescence are a major health problem and often follow a chronic course with severe consequences in later life. Depressive disorders cause the highest burden of disease in this age group across all medical conditions. Treatment adherence is usually very poor, and the use of antidepressant drugs is heavily debated, as suicidal ideations may increase, in particular in the early phase of treatment. Omega-3 fatty acids rich in eicosapentaenoic acid have shown some promising results in over a dozen small scale randomized controlled trials (RCTs) in adult major depressive disorders, with only very few published RCTs in children and adolescents.

Omega-3 fatty acids are also crucially important for brain development. Myelination and synaptic pruning are core processes during normal pubertal brain development. Omega-3 fatty acids supplementation was able to attenuate such depression-like animal behaviors during critical periods of brain development. Furthermore, omega-3 fatty acids have a preventive and neurotrophic effect against structural hippocampal alterations in animal models with depression- and anxiety-like behaviors.

Critical appraisal of omega-3 fatty acids in attention-deficit/hyperactivity disorder treatment

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968854/

Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder. The classical treatment of ADHD where stimulant medication is used has revealed severe side effects and intolerance. Consequently, the demand to search for alternative treatments has increased rapidly. When comparing levels of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) in ADHD patients with those in age-matching controls, lower levels are found in ADHD patients’ blood. ω-3 PUFAs are essential nutrients and necessary for proper brain function and development. Additionally, there are strong indications that ω-3 PUFA supplements could have beneficial effects on ADHD.

The effects and safety of omega-3 fatty for acute lung injury: a systematic review and meta-analysis

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470437/

Acute lung injury (ALI) is a very common kind of critically ill disease in the clinic, which is caused by various intrapulmonary and external factors such as severe trauma, shock, acidosis, or serious infection. If left untreated, it may progress into acute respiratory distress syndrome (ARDS) with high mortality. In the past decade, great progress has been made in the management of patients with ALI and ARDS. However, the mortality of ALI/ARDS is still Omega-3 fatty can effectively improve the respiratory function and promote the recovery of ALI patients. Future studies focused on the long-term efficacy and safety of omega-3 fatty use for ALI are needed.

Effectiveness of omega-3 polyunsaturated fatty acids against microbial pathogens

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964344/

Microorganisms provide both beneficial and harmful effects to human beings. Beneficial effects come from the symbiotic relationship that exists between humans and microbiota, but then several human illnesses have turned some friendly microbes into opportunistic pathogens, causing several microbial-related diseases. Various efforts have been made to create and utilize antimicrobial agents in the treatment and prevention of these infections, but such efforts have been hampered by the emergence of antimicrobial resistance. Despite extensive studies on drug discovery to alleviate this problem, issues with the toxicity and tolerance of certain compounds and continuous microbial evolution have forced researchers to focus on screening various phytochemical dietary compounds for antimicrobial activity.

Therefore, it seems plausible to hypothesize that the inclusion of omega-3 FAs on some prosthetics might help to lessen inflammatory reactions and inhibit microbial growth.

EPA and DHA are omega-3 FAs that have been widely studied for their beneficial effects on human health, mainly the brain, eye, cardiovascular system, and general human growth. However, their utilization as antimicrobial agents has not been widely appreciated perhaps because of little understanding on antimicrobial mechanism. Nonetheless, the efficacy of these agents on microbial cell membranes and their antioxidant properties have been shown to inhibit the growth of microorganisms and thereby promote human health and animal health. Hence, omega-3 FAs can be considered as a potential alternative or adjunctive therapeutic agents because of their antimicrobial and immunomodulatory properties. Moreover, the escalating levels of resistance may be minimized because they have been reported to have little effect on evolving antimicrobial resistance (Desbois and Smith, 2010), and are also safe for human use. Since the development of antimicrobial resistance outruns antimicrobial drug development, it is worthwhile to consider omega-3 FAs in the list of potential antimicrobial agents.

Omega-3 polyunsaturated fatty acid attenuates traumatic brain injury-induced neuronal apoptosis by inducing autophagy through the upregulation of SIRT1-mediated deacetylation of Beclin-1

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225685/

Enhancing autophagy after traumatic brain injury (TBI) may decrease the expression of neuronal apoptosis-related molecules. Autophagy-mediated neuronal survival is regulated by the sirtuin family of proteins (SIRT). Omega-3 polyunsaturated fatty acids (ω-3 PUFA) are known to have antioxidative and anti-inflammatory effects. We previously demonstrated that ω-3 PUFA supplementation attenuated neuronal apoptosis by modulating the neuroinflammatory response through SIRT1-mediated deacetylation of the HMGB1/NF-κB pathway, leading to neuroprotective effects following experimental traumatic brain injury (TBI).

In summary, ω-3 PUFA supplementation inhibited neuronal apoptosis and exerted neuroprotective effects through enhancing the autophagy pathway after TBI. Moreover, ω-3 PUFA increased Beclin-1 deacetylation and its nuclear export and induced direct interactions between cytoplasmic Beclin-1 and Bcl-2 by increasing SIRT1 activity following TBI; subsequently leading to inhibition of neuronal apoptosis. These results indicate that ω-3 PUFA supplementation attenuates TBI-induced neuronal apoptosis by inducing the autophagy pathway through the upregulation of SIRT1-mediated deacetylation of Beclin-1.

Protective effects of omega‐3 fatty acids against Alzheimer’s disease in rat brain endothelial cells

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236236/

Omega‐3 fatty acids are well‐known unsaturated fatty acids that are essential for growth and development in animals. They primarily participate in the development of intelligence, the nervous system, and vision, and the metabolism of neurotransmitters. Omega‐3 fatty acids have been widely studied in the treatment of Alzheimer’s disease (AD). Omega‐3 fatty acids are known to have neuroprotective effects due to their antioxidant capacity. Rotenone has been shown to induce neurotoxicity in vitro.

Studies suggest that omega‐3 fatty acids show potential as a therapeutic agent against AD.

Effects of Omega 3 Fatty Acids on Main Dimensions of Psychopathology

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504659/

The usefulness of polyunsaturated fatty acids on inflammatory, cardiovascular, and the nervous system was studied in the last decades, but the mechanisms underlying their benefic properties are still partially unknown. These agents seem to express their action on the membrane phospholipid composition and permeability and modulation of second messenger cascades. In psychiatry, the efficacy and tolerability of omega-3 fatty acids were investigated in several psychiatric disorders, including major depression, bipolar disorder, personality disorders, high-risk conditions to develop psychosis, attention-deficit hyperactivity disorder, and autism spectrum disorders. Initial findings in this field are promising, and some relevant questions need to be addressed.

Preclinical studies hypothesized that omega-3 fatty acids may attenuate stress-related changes in animals with depressive features, as well as in humans. These agents seem to be involved in myelinization processes and synaptic pruning, which are fundamental processes during brain development. PUFAs have immune-modulatory, and anti-inflammatory properties through the modulation of omega-6 fatty acids and the promotion of resolvins, neuroprotective factors, and anti-inflammatory mediators. They are also involved in membrane fluidity producing an improvement of monoaminergic transmission.

In the last decades, the role of long-chain PUFAs in the treatment of several psychiatric disorders has gradually increased, as confirmed by the growing number of randomized controlled trials testing the efficacy of essential fatty acids, especially omega-3 supplementation.

Beneficial effects of omega-3 fatty acid supplementation in schizophrenia: possible mechanisms

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333328/

Schizophrenia is a serious long-term psychotic disorder marked by positive and negative symptoms, severe behavioral problems, and cognitive function deficits. The cause of this disorder is not completely clear but is suggested to be multifactorial, involving both inherited and environmental factors. Since the human brain regulates all behavior, studies have focused on identifying changes in neurobiology and biochemistry of the brain in schizophrenia. The brain is the most lipid-rich organ (approximately 50% of brain dry weight). Total brain lipids are constituted of more than 60% of phospholipids, in which docosahexaenoic acid (DHA, 22:6n-3) is the most abundant (more than 40%) polyunsaturated fatty acid (PUFA) in brain membrane phospholipids. Results from numerous studies have shown significant decreases of PUFAs, in particular, DHA in peripheral blood (plasma and erythrocyte membranes) as well as brain of schizophrenia patients at different developmental phases of the disorder. PUFA deficiency has been associated to psychotic symptoms and cognitive deficits in schizophrenia.

Omega-3 fatty acid supplementation reduced the conversion rate to psychosis and improved both positive and negative symptoms and global functions in adolescents at ultra-high risk for psychosis. Omega-3 fatty acid supplementation could also improve negative symptoms and global functions in the first-episode patients with schizophrenia, but improve mainly total or general PANSS subscales in chronic patients. Patients with low PUFA (particularly DHA) baseline in blood were more responsive to the omega-3 fatty acid intervention.

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